Dimethyl Sulfoxide → HCID 22936580, compound

HRID 1010412Notes

Reaction equation

HRID 1010412 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[CH3:32])C=CC=CC=1.CS(C)=O.[CH3:38][NH2:39].O1CCCC1>C(OCC)(=O)C.O>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:39][CH3:38])=[O:7])=[C:11]([CH3:32])[CH:12]=1)(=[O:29])[NH2:28]

Participants

7

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6329MethylamineHCID 8028TetrahydrofuranHCID 58931269HCID 58931269, compound

Product 1

HCID 22936580HCID 22936580, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

[4-(6-Carbamoyl-7-methoxy-4-quinolyl)oxy-2-methylphenyl]carbamic acid phenyl ester (70 mg) was added to dimethylsulfoxide (0.8 ml), and then a methylamine-containing 2N tetrahydrofuran solution (0.4 ml) was added and the mixture was stirred for 5 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (48 mg).

Workup

  1. additionwas added
  2. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-ad15ee0bb6af4a79a2facc07f870c294
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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