Triethylamine → 2{[(6-Chloro(3-pyridyl))methyl]propylamino}ethan-1-ol

HRID 1010538Notes

Reaction equation

HRID 1010538 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH2:10][CH2:11][OH:12])=[CH:4][CH:3]=1.I[CH2:14][CH2:15][CH3:16].C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:14][CH2:15][CH3:16])[CH2:10][CH2:11][OH:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 336431-IodopropaneHCID 153902972-[(6-Chloro-pyridin-3-ylmethyl)-amino]-ethanol

Product 1

HCID 614249322{[(6-Chloro(3-pyridyl))methyl]propylamino}ethan-1-ol

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound was made in a manner analogous to that set forth in Step B of Example 2, using 11.3 grams (about 0.055 mole) of 2-{[(6-chloro-3-pyridyl)methyl]amino}ethan-1-ol, 25.4 grams (0.150 mole) of 1-iodopropane, and 14.5 grams (0.143 mole) of triethylamine in 50 mL of acetonitrile. The yield of the subject compound was about 2.2 grams.

Sources & evidence

ORD record
ord-c8075ee458f84ecdb767596ff2d08256
Source dataset
uspto-grants-2011_07
Patent number
US07977332B2

Reaction notes

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