Benzyl chloroformate → HCID 67315607, compound

HRID 1010705Notes

Reaction equation

HRID 1010705 reaction equation
[O:1]=[C:2]1[NH:6][C@@H:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:4][CH2:3]1.Cl[C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]>C1COCC1>[O:1]=[C:2]1[N:6]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[C@@H:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 10387Benzyl chloroformateHCID 643508ethyl (2R)-5-oxopyrrolidine-2-carboxylate

Product 1

HCID 67315607HCID 67315607, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

9.1 Reaction of 1.0 g of ethyl(R)-5-oxopyrrolidine-2-carboxylate, 949.8 μl of benzyl chloroformate, 6.9 ml of bis(trimethylsilyl)lithium amide (in THF) in 25 ml of THF under standard conditions and work-up gives 730 mg of ethyl(R)-5-oxo-N-benzyloxycarbonylpyrrolidine-2-carboxylate (“17”).

Sources & evidence

ORD record
ord-a65930fc04e24caa890b77a73a1bab32
Source dataset
uspto-grants-2011_07
Patent number
US07977343B2

Reaction notes

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