反应详情

A solution of N-trifluoroacetyl-1-(2-iodo-5-methoxyphenyl)-2-propylamine (6.09 g, 15.7 mmol) in toluene (450 mL) was treated with K2CO3 (2.82 g, 20.4 mmol), KOH (2.45 g, 47.1 mmol), n-Bu4NBr (0.506 g, 1.57 mmol) and allyl bromide (2.47 g, 20.4 mmol), and stirred overnight at 80 C. The product mixture was acidified with 10% aqueous HCl, separated, the aqueous phase extracted with ether (500 mL), the combined organic phases were washed with brine (200 mL), dried with Na2SO4 and concentrated to give 4.45 g of a brown oil.

1. customseparated
2. extractionthe aqueous phase extracted with ether (500 mL)
3. washthe combined organic phases were washed with brine (200 mL)
4. dry with materialdried with Na2SO4
5. concentrationconcentrated