2-Bromoethanol → 10-(2-hydroxyethyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane

HRID 1010795Notes

Reaction equation

HRID 1010795 reaction equation
[CH2:1]1[C:3]2([CH2:11][NH:10][CH2:9][C:4]32[O:8][CH2:7][CH2:6][O:5]3)[CH2:2]1.Br[CH2:13][CH2:14][OH:15].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:15][CH2:14][CH2:13][N:10]1[CH2:11][C:3]2([CH2:1][CH2:2]2)[C:4]2([O:5][CH2:6][CH2:7][O:8]2)[CH2:9]1

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 224172225,8-Dioxa-10-azadispiro[2.0.4.3]undecane

Product 1

HCID 1673849810-(2-hydroxyethyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The compound (B) (100 mg) was mixed with 2-Bromoethanol (100 mg) and K2CO3 (120 mg) in Acetonitrile. The reaction was refluxed overnight and filtered, the filtrate was evaporated and purified on silica gel column to give the titled product. Mass: (M+1), 200

Workup

  1. temperatureThe reaction was refluxed overnight
  2. filtrationfiltered
  3. customthe filtrate was evaporated
  4. custompurified on silica gel column

Sources & evidence

ORD record
ord-68da0bef6e6647ec8ad3506260f2ab14
Source dataset
uspto-grants-2011_07
Patent number
US07977346B2

Reaction notes

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