Hydrochloric Acid → HCID 76798883, compound

A solution of 5-fluoro-1,3-dihydro-indol-2-one (825 mg, 5.46 mmol.) in THF (5 mL) is cooled to 0° C. under an Argon atmosphere and treated with a solution of lithium bis(trimethylsilyl)amide (11 mL of a 1 M solution in THF, 11 mmol) dropwise. The resulting solution is stirred at room temperature for 10 min. A solution of 4-chloro-3H-furo[3,4-c]pyridin-1-one (620 mg, 3.67 mmol) in THF (7 mL) is added dropwise to the reaction mixture. The resulting solution is stirred for 4 h. The reaction mixture is poured into aqueous 10% HCl solution (160 mL). The resulting mixture is heated to 90° C. for 2 h and then stirred at room temperature for 36 h. The precipitate which formed is collected by filtration, washed with small volumes of ethyl acetate (10×3 mL) and dried under vacuum to give the title compound as a yellow solid (810 mg, 73%).

1. stirringThe resulting solution is stirred for 4 h
2. temperatureThe resulting mixture is heated to 90° C. for 2 h
3. stirringstirred at room temperature for 36 h
4. customThe precipitate which formed
5. filtrationis collected by filtration
6. washwashed with small volumes of ethyl acetate (10×3 mL)
7. customdried under vacuum

ORD record

ord-567bbe87073549959709575d570fa31b

Source dataset

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07977351B2