Lithium Hydroxide → HCID 23159767, compound

HRID 1011426Notes

Reaction equation

HRID 1011426 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:13]=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li+].[OH-]>C1COCC1.O>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[CH:13]=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 23159744HCID 23159744, compound

Product 1

HCID 23159767HCID 23159767, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl 5-benzyloxyquinoline-3-carboxylate (3.07 g, 10 mmol) prepared in stage A and LiOH (0.4 g, 20 mmol) in THF (20 mL)and water (0.5 mL) was refluxed for 2 hours. After cooling, the solvents were evaporated under vacuum. The solid residue was used in the next step without further purification.

Workup

  1. temperatureAfter cooling
  2. customthe solvents were evaporated under vacuum
  3. customThe solid residue was used in the next step without further purification

Sources & evidence

ORD record
ord-2fe2595dad2c42a7a6f6bc0ac23bf8f9
Source dataset
uspto-grants-2011_07
Patent number
US07977354B2

Reaction notes

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