反应详情

温度

60 °C

To a solution of methyl 3-hydroxy-5-[(1-methylethyl)oxy]benzoate (25 g) in DMF (250 mL) was added anhydrous potassium carbonate (297 mmol), and benzyl bromide (143 mmol). The mixture was stirred at 60° C. for 5 hours, then cooled to room temperature. The solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organics were combined and washed with further water, brine, dried (MgSO4) and concentrated in vacuo to give the desired compound (37 g) which was used without further purification.

1. temperaturecooled to room temperature
2. customThe solvent was removed in vacuo
3. customthe residue partitioned between ethyl acetate and water
4. washwashed with further water, brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo