Hydrochloric Acid → (7-Azabicyclo[2.2.1]heptan-7-yl)(5,6-dichloropyridin-3-yl)methanone
Reaction equation
C(Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[C:9]([Cl:17])=[N:10][CH:11]=[C:12]([CH:16]=1)[C:13]([OH:15])=O.Cl.O1CCOCC1.Cl.[CH:26]12[NH:32][CH:29]([CH2:30][CH2:31]1)[CH2:28][CH2:27]2.C(N(CC)CC)C>C(Cl)Cl>[Cl:7][C:8]1[CH:16]=[C:12]([C:13]([N:32]2[CH:26]3[CH2:31][CH2:30][CH:29]2[CH2:28][CH2:27]3)=[O:15])[CH:11]=[N:10][C:9]=1[Cl:17]Participants
Reactant 6
Product 1
Reagents, catalysts & solvents 1
Procedure
Oxalyl chloride (3.2 mL; 36.0 mmol) was added to a solution of 5,6 dichloronicotinic acid (5.76 g, 30.0 mmol) and 4M hydrogen chloride in dioxane (7.5 mL; 30.0 mmol) in DCM (50 mL). The mixture was stirred at RT for 18 hours, the DCM evaporated in vacuo, the residue azeotroped with toluene (2×15 mL) and added to a solution of 7-azabicyclo[2.2.1]heptane hydrochloride (4.75 g; 36.0 mmol) and triethylamine (15.1 mL; 108 mmol) in DCM (150 mL). The mixture was stirred at RT for 18 hours, the DCM evaporated in vacuo and the residue partitioned between water (75 mL) and ethyl acetate (150 mL). The organic layer was washed with brine, dried (MgSO4) and evaporated to give a solid which was crystallised from ethyl acetate to give the desired compound (5.45 g).
Workup
- customthe DCM evaporated in vacuo
- customthe residue azeotroped with toluene (2×15 mL)
- stirringThe mixture was stirred at RT for 18 hours
- customthe DCM evaporated in vacuo
- customthe residue partitioned between water (75 mL) and ethyl acetate (150 mL)
- washThe organic layer was washed with brine
- dry with materialdried (MgSO4)
- customevaporated
- customto give a solid which
- customwas crystallised from ethyl acetate
Sources & evidence
- ORD record
- ord-d92a764feef54fdf8e6b7711831f69e0
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07977328B2
Reaction notes
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