Hydrochloric Acid → HCID 58677597, compound

HRID 1012645Notes

Reaction equation

HRID 1012645 reaction equation
CC1(C)[O:6][CH:5]([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([CH3:35])=[C:13]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=4[CH3:31])=[CH:19][C:18]=3[N+:32]([O-:34])=[O:33])=[O:16])[CH:14]=2)[CH2:4][O:3]1.Cl>C1COCC1>[OH:6][CH:5]([CH2:4][OH:3])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:35])=[C:13]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[CH3:31])=[CH:19][C:18]=2[N+:32]([O-:34])=[O:33])=[O:16])[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58677643HCID 58677643, compound

Product 1

HCID 58677597HCID 58677597, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 301 (0.025, 0.05 mmol) was dissolved in THF (2 mL) and 1 M HCl (0.2 mL) was added. The solution was kept at room temperature for 3 h after which the solution was concentrated in vacuo. This afforded the title compound. 1H NMR (CDCl3) δ 7.36 (d, 1H), 7.22 (dd, 1H), 7.18 (d, 1H), 7.10 (d, 1H), 7.06-6.88 (m, 3H), 6.87-6.77 (m, 2H), 5.89 (bs, 1H), 4.05 (m, 1H), 3.95 (m, 2H), 3.85-3.65 (m, 2H), 2.46 (s, 3H), 2.25 (s, 3H)

Workup

  1. concentrationafter which the solution was concentrated in vacuo

Sources & evidence

ORD record
ord-ed5602e341924467aa18e97d96301b92
Source dataset
uspto-grants-2011_07
Patent number
US07977387B2

Reaction notes

Loading…