Tetrahydrofuran → HCID 66600098, compound

HRID 101271Notes

Reaction equation

HRID 101271 reaction equation
[CH3:2][Si:3]([N-:4][Si:5]([CH3:6])([CH3:7])[CH3:8])([CH3:9])[CH3:10].[F:11][c:12]1[c:13](-[c:32]2[c:33]3[n:34][cH:35][n:36]([CH:42]4[O:43][CH2:44][CH2:45][CH2:46][CH2:47]4)[c:37]3[n:38][c:39]([CH3:41])[n:40]2)[cH:14][c:15]([CH2:18][N:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]2)[cH:16][n:17]1.[Li+:1].[NH2:48][c:49]1[cH:50][n:51][c:52]([O:55][CH3:56])[cH:53][cH:54]1.[O:57]1[CH2:58][CH2:59][CH2:60][CH2:61]1>>[c:12]1([NH:48][c:49]2[cH:50][n:51][c:52]([O:55][CH3:56])[cH:53][cH:54]2)[c:13](-[c:32]2[c:33]3[n:34][cH:35][n:36]([CH:42]4[O:43][CH2:44][CH2:45][CH2:46][CH2:47]4)[c:37]3[n:38][c:39]([CH3:41])[n:40]2)[cH:14][c:15]([CH2:18][N:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]2)[cH:16][n:17]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 811216-Methoxy-3-pyridinylamineHCID 3280088Npc316347HCID 59548429tert-butyl 4-((6-fluoro-5-(2-methyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

Product 1

HCID 66600098HCID 66600098, compound

Sources & evidence

ORD record
ord-e540b3a01b1b481a9b2bfc8c0380d169
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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