Hydrochloric Acid → HCID 57925897, compound

HRID 1013478Notes

Reaction equation

HRID 1013478 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([P:13]([O:17][CH3:18])([O:15][CH3:16])=[O:14])([F:12])[CH3:11])=[CH:6][CH:5]=1.[Li+].[OH-].Cl>O1CCOCC1>[CH3:16][O:15][P:13]([C:10]([C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:19])=[O:2])=[CH:9][CH:8]=1)([F:12])[CH3:11])([O:17][CH3:18])=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57925946HCID 57925946, compound

Product 1

HCID 57925897HCID 57925897, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-[1-(Dimethoxy-phosphoryl)-1-fluoro-ethyl]-benzoic acid methyl ester (0.56 g, 1.93 mmol) was made 0.25 M in dioxane and to this stirring solution was added 3 M aqueous LiOH (0.14 g, 5.79 mmol). The resulting mixture was stirred at ambient temperature for 18 hours. The mixture was neutralized with 1N aq HCl and concentrated in vacuo. The residue was carried forward without further purification: MS: cal'd 277 (MH+), exp 277 (MH+)

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was carried forward without further purification

Sources & evidence

ORD record
ord-be3de6d22f5945ba8ef7184d49e5af94
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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