Hydrochloric Acid → HCID 57925869, compound

HRID 1013525Notes

Reaction equation

HRID 1013525 reaction equation
[CH3:1][O:2][P:3]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=1)([O:5][CH3:6])=[O:4].[Li+].[OH-].Cl>O1CCOCC1>[CH3:1][O:2][P:3]([NH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)([O:5][CH3:6])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 57925820HCID 57925820, compound

Product 1

HCID 57925869HCID 57925869, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methyl 4-[(dimethoxyphosphoryl)amino]benzoate (1.50 g, 5.79 mmol) was made 0.25 M in dioxane and to this stirring solution was added 3M aq LiOH. The resulting solution was stirred at ambient temperature for 16 h. The reaction mixture was then neutralized to pH=7 with 1N aq HCl and concentrated in vacuo to afford the requisite product. MS: cal'd 243 (MH+), exp 243 (MH+)

Workup

  1. concentrationconcentrated in vacuo
  2. customto afford the requisite product

Sources & evidence

ORD record
ord-90d1af767f404b479a42fbaebee09497
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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