反应详情

Treat a solution of 2,6-Dimethyl-4-hydroxybenzaldehyde (4.0 g, 27 mmol) and benzyl bromide (3.3 mL, 28 mmol) in DMF (50 mL) with Potassium carbonate (4.5 g, 32 mmol). Heat the reaction to 60° C. and stir for 1 hr. Cool the reaction and quench with 1N aqueous HCl. Extract the aqueous with Et2O. Wash the organic with brine, dry over MgSO4, and filter. Remove the solvent to afford 6.4 g (100%) of product. 1H NMR (d6-CDCl3) δ 10.46 (s, 1H), 7.31-7.43 (m, 5H), 6.65 (s, 2H), 5.08 (s, 2H), 2.58 (s, 6H).

1. temperatureHeat
2. customthe reaction to 60° C.
3. temperatureCool
4. customthe reaction
5. customquench with 1N aqueous HCl
6. extractionExtract the aqueous with Et2O
7. washWash the organic with brine
8. dry with materialdry over MgSO4
9. filtrationfilter
10. customRemove the solvent