Ammonium → Methyl 5-fluoromethoxypyridine-2-carboxylate

HRID 101466Notes

Reaction equation

HRID 101466 reaction equation
[C:25](=[O:26])([O-:27])[O-:28].[CH3:38][CH2:39][O:40][C:41](=[O:42])[CH3:43].[Cl-:31].[Cs+:29].[Cs+:30].[NH4+:32].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[OH:14][c:15]1[cH:16][cH:17][c:18]([C:21](=[O:22])[O:23][CH3:24])[n:19][cH:20]1.[c:1]1([CH3:2])[cH:3][cH:4][c:5]([S:6]([O:7][CH2:11][F:12])(=[O:8])=[O:9])[cH:10][cH:13]1>>[CH2:11]([F:12])[O:14][c:15]1[cH:16][cH:17][c:18]([C:21](=[O:22])[O:23][CH3:24])[n:19][cH:20]1

Participants

9

Reactant 8

HCID 223AmmoniumHCID 312ChlorideHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 4715126Methyl 5-hydroxypyridine-2-carboxylateHCID 13862289Fluoromethyl 4-methylbenzenesulfonate

Product 1

HCID 57827265Methyl 5-fluoromethoxypyridine-2-carboxylate

Sources & evidence

ORD record
ord-dd53ac7b409743549226e6a792ad2656
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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