Triethylsilane → HCID 67301422, compound

HRID 1015373Notes

Reaction equation

HRID 1015373 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]1)=O.C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][CH:6]1[CH2:11][CH2:10][CH:9]([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 178525725HCID 178525725, compound

Product 1

HCID 67301422HCID 67301422, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Trans-4-(2-chlorobenzoyl)cyclohexane-1-carboxylic acid (300 mg; 1.12 mmol) and triethylsilane (654 mg; 5.62 mmol) was carried out using Method G in 4 mL of trifluoroacetic acid. Title compound was obtained as a white solid. (118 mg; 42% yield).

Sources & evidence

ORD record
ord-e91b5f9ac8294aeab6790cbd5d92165c
Source dataset
uspto-grants-2011_07
Patent number
US07985755B2

Reaction notes

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