反应详情

5-Methylisophthalic acid (1.21 g, 6.5 mmol), dichloroethane (20 mL), DMF (3 drops), and thionyl chloride (2.42 g, 20 mmol) was heated to 80° C. for 4 hrs. The reaction was concentrated to dryness and a solution of MeOH (208 mg, 6.5 mmol) was added slowly and the reaction was stirred overnight at rt. 1 N Hydrochloric acid (10 mL) was added and reaction stirred for 1 hr. The pH was adjusted with sat'd sodium bicarbonate (50 mL) and the aqueous solution was extracted with methylene chloride to remove the diester. The aqueous portion was then acidified with 1 N HCl and extracted with methylene chloride/MeOH 95:5. The organic extracts were dried over sodium sulfate, filtered, concentrated, and the product was isolated via preparative reverse-phase HPLC.

1. concentrationThe reaction was concentrated to dryness
2. customreaction
3. stirringstirred for 1 hr
4. extractionthe aqueous solution was extracted with methylene chloride
5. customto remove the diester
6. extractionextracted with methylene chloride/MeOH 95:5
7. dry with materialThe organic extracts were dried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customthe product was isolated via preparative reverse-phase HPLC