反应详情

温度

90 °C

To a 5 liter 1-necked round bottomed flask equipped with mechanical stirrer was added 502.5 grams (1.65 mole) of 3-pentadecylphenol, 200 grams (1.45 mole) of potassium carbonate, and 2,000 grams of 1-methyl-2-pyrrolidinone (anhydrous; obtained from Aldrich Chemical Co.). The mixture was heated to 90° C. for 2 hours using a heating mantle. The reaction mixture turned dark brown. Thereafter, 250.0 grams (1.45 mole) of 4-nitrophthalonitrile (obtained from Sigma-Aldrich) was added and the mixture was maintained at 90° C. for an additional 2 hours. The hot reaction mixture was then quenched by slowly pouring it into 3 liters of deionized water. The precipitated beige suspension was stirred until it had cooled to room temperature, then was filtered. The solid was then reslurried and filtered, using about 6 liter portions of deionized water, until the water used to wash the solid product was of neutral pH. The solid was then twice reslurried in 4 liters of methanol, filtered, and vacuum dried at 40° C. to give 519.8 grams (84 percent yield) of 4-(3-pentadecyl) phenoxyphthalonitrile. The purity of this material as measured by HPLC was more than 89 percent.

1. customTo a 5 liter 1-necked round bottomed flask equipped with mechanical stirrer
2. temperaturethe mixture was maintained at 90° C. for an additional 2 hours
3. customThe hot reaction mixture was then quenched
4. additionby slowly pouring it into 3 liters of deionized water
5. temperaturehad cooled to room temperature
6. filtrationwas filtered
7. filtrationfiltered
8. washto wash the solid product
9. filtrationfiltered
10. customvacuum dried at 40° C.