Lithium Hydroxide → HCID 22038825, compound

HRID 1016751Notes

Reaction equation

HRID 1016751 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]([C:16]2[CH:21]=[C:20]([O:22][CH2:23][CH3:24])[CH:19]=[CH:18][C:17]=2[O:25][CH2:26][C:27](=[O:29])[NH2:28])[C:12]([O:14]C)=[O:13])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].[Li+].[OH-]>C1COCC1>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]([C:16]2[CH:21]=[C:20]([O:22][CH2:23][CH3:24])[CH:19]=[CH:18][C:17]=2[O:25][CH2:26][C:27](=[O:29])[NH2:28])[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)(=[NH:2])[NH2:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86583530HCID 86583530, compound

Product 1

HCID 22038825HCID 22038825, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The methyl (RS)-(4-carbamimidoyl-phenylamino)-(2-carbamoylmethoxy-5-ethoxy-phenyl)-acetate was saponified in THF with 1N LiOH to give (RS)-(4-carbamimidoyl-phenylamino)-(2-carbamoylmethoxy-5-ethoxy-phenyl)-acetic acid and purified by trituration in water and dilute ammonia; m.p. 266° C., MS: 387 (M+H)+.

Sources & evidence

ORD record
ord-95d8d845399442d4a3036190ced5d45e
Source dataset
uspto-grants-2002_11
Patent number
US06476264B2

Reaction notes

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