Acetonitrile → HCID 9838264, compound

HRID 1017700Notes

Reaction equation

HRID 1017700 reaction equation
C(O[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)CC.[C:14]([O:17][CH2:18][CH3:19])(=O)C.C[O-].[Na+].[C:23]([CH2:25][C:26]([NH2:28])=[O:27])#[N:24].[C:29](#N)[CH3:30]>>[C:23]([C:25]1[C:26](=[O:27])[NH:28][C:10]([C:9]2[CH:8]=[CH:6][CH:5]=[CH:19][C:18]=2[O:17][CH2:14][CH2:29][CH3:30])=[CH:11][C:12]=1[CH3:13])#[N:24]

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 7898CyanoacetamideHCID 8857Ethyl AcetateHCID 10942334Sodium MethoxideHCID 12715559HCID 12715559, compound

Product 1

HCID 9838264HCID 9838264, compound

Procedure

In a similar manner to that of Example 26, 2-propoxyacetophenone (8.9 g) was allowed to react with ethyl acetate in the presence of sodium methoxide, and the intermediate was cyclised with cyanoacetamide to give the title compound, 0.2 g, m.p. 180°-180.5° C. (from acetonitrile).

Sources & evidence

ORD record
ord-2e41650f2cd440d1897cf56cb6e7e905
Source dataset
uspto-grants-2002_11
Patent number
US06479520B1

Reaction notes

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