反应详情

A mixture of 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (0.1 g, 0.21 mmol), potassium carbonate (59 mg, 0.42 mmol), CuCl (2 mg, 0.021 mmol), tris[2-(2-methoxyethoxy)-ethyl]-amine (1.5 μL) and 4,6-dichloropyrimidine (32 mg, 0.21 mmol) in xylene (5 mL) was stirred and boiled for 18 h. The mixture was cooled, washed with water, ammonia in water (10%) and water again. Evaporation of the solvent yielded a residue which was purified by chromatography on silica gel (ethyl acetate/n-hexane 1:2) to yield the desired product (29 mg, 24%), m.p. 212-214° C. and MS: m/e=584.1 (M+H+).

1. temperatureThe mixture was cooled
2. washwashed with water, ammonia in water (10%) and water again
3. customEvaporation of the solvent
4. customyielded a residue which
5. customwas purified by chromatography on silica gel (ethyl acetate/n-hexane 1:2)