Hydrochloric Acid → HCID 88064075, compound

HRID 1018910Notes

Reaction equation

HRID 1018910 reaction equation
[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19](Cl)(=[O:21])=[O:20])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].Cl.C(OCC)(=O)C.[OH-].[NH4+:33]>>[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19]([NH2:33])(=[O:21])=[O:20])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 88063986HCID 88063986, compound

Product 1

HCID 88064075HCID 88064075, compound

Procedure

A suspension of the compound obtained in Step E of Example 1 (1.26 g, 3.0 mmol) in 18 ml of 28% ammonium hydroxide solution is stirred. After a few minutes the batch is observed to pass into solution. Stirring is maintained for 30 minutes and the reaction mixture is rendered acidic with 4N HCl. A few ml of ethyl acetate are added with stirring and precipitation occurs. The precipitate is filtered off and dried in vacuo to yield the title product in the form of a cream-coloured powder.

Workup

  1. waitAfter a few minutes the batch is observed
  2. stirringStirring
  3. temperatureis maintained for 30 minutes
  4. stirringwith stirring
  5. customprecipitation
  6. filtrationThe precipitate is filtered off
  7. customdried in vacuo

Sources & evidence

ORD record
ord-85e8f56f937a42168a42660fc3b02afe
Source dataset
uspto-grants-2002_11
Patent number
US06486143B2

Reaction notes

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