Hydrochloric Acid → HCID 12051207, compound

HRID 1019076Notes

Reaction equation

HRID 1019076 reaction equation
[CH2:1]([C:3]1[C:11]2[NH:10][CH:9]=[N:8][C:7]=2[C:6]([CH3:12])=[CH:5][C:4]=1[NH:13]C=O)[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl.[OH-].[NH4+]>CO>[NH2:13][C:4]1[CH:5]=[C:6]([CH3:12])[C:7]2[N:8]=[CH:9][NH:10][C:11]=2[C:3]=1[CH2:1][CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 14923Ammonium HydroxideHCID 12051206HCID 12051206, compound

Product 1

HCID 12051207HCID 12051207, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-ethyl-5-formamido-7-methylbenzimidazole (1.7 g, 8.36 mmol), potassium carbonate (2.0 g, 14.4 mmol) and 6N hydrochloric acid (34 mL) in methanol (34 mL) is heated to reflux for 1 hour. The mixture is cooled to room temperature, brought to pH 9 with ammonium hydroxide and rotary evaporated. The residue is purified by flash chromatography on silica gel (chloroform:methanol 9:1) to afford 5-amino-4-ethyl-7-methylbenzimidazole as a tan solid.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 1 hour
  3. customThe residue is purified by flash chromatography on silica gel (chloroform:methanol 9:1)

Sources & evidence

ORD record
ord-c0567bb705284afc930d51a2688875ca
Source dataset
uspto-grants-2002_11
Patent number
US06486190B1

Reaction notes

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