4-Iodophenol → HCID 18401150, compound

HRID 1019350Notes

Reaction equation

HRID 1019350 reaction equation
Br[CH2:2][CH2:3][CH2:4][N:5]1[C:9](=[O:10])[C:8]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:7]2[C:6]1=[O:15].[I:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[I:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:2][CH2:3][CH2:4][N:5]2[C:9](=[O:10])[C:8]3=[CH:11][CH:12]=[CH:13][CH:14]=[C:7]3[C:6]2=[O:15])=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 108944-IodophenolHCID 11430Potassium CarbonateHCID 21611N-3-Bromopropylphthalimide

Product 1

HCID 18401150HCID 18401150, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-(3-bromopropyl)phthalimide (1 eq., Aldrich), 4-iodophenol (1 eq., Aldrich) and potassium carbonate (2 eq.) were stirred in acetonitrile. The mixture was heated at reflux. After 64 hours, the reaction mixture was concentrated to a thick mixture which was slurried in water. A white solid was collected, washed with water and vacuum dried to provide 1-(4-iodophenoxy)-3-(phthalimido)propane.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. concentrationthe reaction mixture was concentrated to a thick mixture which
  4. customA white solid was collected
  5. washwashed with water and vacuum
  6. customdried

Sources & evidence

ORD record
ord-9a1570c1ed554772b415e454b13488a7
Source dataset
uspto-grants-2002_11
Patent number
US06486350B1

Reaction notes

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