Hydrochloric Acid → HCID 67481568, compound

HRID 1019653Notes

Reaction equation

HRID 1019653 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[N:19]=[C:18]([N:20]3[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH:22]([C:33]([O:35]C)=[O:34])[CH2:21]3)[CH:17]=[CH:16][N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].O.[OH-].[Li+].Cl>O1CCOCC1.O.C(Cl)Cl>[C:29]([O:28][C:26]([N:23]1[CH2:24][CH2:25][N:20]([C:18]2[CH:17]=[CH:16][N:15]=[C:14]([NH:13][C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:19]=2)[CH2:21][CH:22]1[C:33]([OH:35])=[O:34])=[O:27])([CH3:32])([CH3:30])[CH3:31]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67481512HCID 67481512, compound

Product 1

HCID 67481568HCID 67481568, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To 2.2 (0.05 g, 0.099 mmol) in dioxane (0.331 mL) was added lithium hydroxide monohydrate (6.25 mg, 0.149 mmol) in water (0.331 mL). The reaction was stirred at room temperature for 1 hour. The reaction was then acidified with 1N HCl and diluted with DCM. The organic layer was extracted, dried over Na2SO4, filtered and concentrated to provide 2.3 as a light yellow solid. ESI-MS M+H 490.0.

Workup

  1. extractionThe organic layer was extracted
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-e4de9206ee984f979b9a81056e110635
Source dataset
uspto-grants-2014_05
Patent number
US08716281B2

Reaction notes

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