Ethyl Acetate → 3-(2-Bromo-4-chloropyridin-3-yl)oxetan-3-ol

To a solution of 2-bromo-4-chloropyridine (14 g, 70 mmol) in dry THF (200 mL) was added LDA (42.0 mL, 84.0 mmol, 2.0 M) dropwise at −70° C. After stirring for 0.5 h at this temperature, a solution of oxetan-3-one (6.6 g, 90 mmol) in dry THF (40 mL) was added slowly and the reaction mixture was stirred at 0° C. for an additional 1 h. Saturated aqueous NH4CI (50 mL) and EA (200 mL) were added. The mixture was partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with water and brine. After drying over anhydrous magnesium sulfate, the solvent was evaporated and the crude material was purified by SGC eluting with DCM) to afford 148a as a yellow solid (8.8 g, 45%). MS: [M+H]+ 266.0.

1. stirringthe reaction mixture was stirred at 0° C. for an additional 1 h
2. customThe mixture was partitioned between water and ethyl acetate
3. extractionThe aqueous layer was extracted with ethyl acetate
4. washThe combined organic layer was washed with water and brine
5. dry with materialAfter drying over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. customthe crude material was purified by SGC
8. washeluting with DCM)

ORD record

ord-f1f51d605c4f495fb6b46d6634cc40f8

Source dataset

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08716274B2