Methyl Acrylate → HCID 11230741, compound

HRID 1022525Notes

Reaction equation

HRID 1022525 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=[O:6].[C:11]([O:15][CH3:16])(=[O:14])[CH:12]=[CH2:13].N12CCN(CC1)CC2>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]([OH:6])[C:12](=[CH2:13])[C:11]([O:15][CH3:16])=[O:14])[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

5

Reactant 3

HCID 7294Methyl AcrylateHCID 9237DabcoHCID 227103,4-Dichlorobenzaldehyde

Product 1

HCID 11230741HCID 11230741, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3,4-dichlorobenzaldehyde (17.5 g) and methyl acrylate (8.6 mL) in acetonitrile (100 ml) was added 1,4-diazabicyclo[2.2.2]octane (3.36 g), and the mixture was stirred at room temperature for 2 days. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (18.7 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel chromatography (hexane/ethyl acetate)

Sources & evidence

ORD record
ord-c18b96f60f144edd83b26b5709cbc575
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

Loading…