反应详情

To a solution of tert-butyl (6R,7R)-6-(cyanomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (1 g) in DMSO (10 mL) were added potassium carbonate (0.502 g) and 30% aqueous hydrogen peroxide (1.22 mL) at room temperature. The reaction mixture was stirred at room temperature for 1.5 hr. Diluted aqueous sodium thiosulfate solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (746 mg).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography