反应详情

A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (5.75 g).

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. extractionthe mixture was extracted with ether (three times)
4. dry with materialThe organic extracts were dried (MgSO4)
5. customevaporated
6. custompurified by chromatography (silica, petrol-ether as eluent)