Potassium Carbonate → 2-[2-(Benzyloxy)-4-ethylphenoxy]-6-fluoropyridine

HRID 1023896Notes

Reaction equation

HRID 1023896 reaction equation
C([O-])([O-])=O.[K+].[K+].[CH2:7]([O:14][C:15]1[CH:20]=[C:19]([CH2:21][CH3:22])[CH:18]=[CH:17][C:16]=1[OH:23])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[F:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27](F)[N:26]=1>C(#N)C>[CH2:7]([O:14][C:15]1[CH:20]=[C:19]([CH2:21][CH3:22])[CH:18]=[CH:17][C:16]=1[O:23][C:27]1[CH:28]=[CH:29][CH:30]=[C:25]([F:24])[N:26]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 739342,6-DifluoropyridineHCID 591912432-(Benzyloxy)-4-ethylphenol

Product 1

HCID 591913542-[2-(Benzyloxy)-4-ethylphenoxy]-6-fluoropyridine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

To a suspension of K2CO3 (0.25 mmol; 35 mg) in anhydrous acetonitrile (2 mL) under argon, was added 2-Benzyloxy-4-ethyl-phenol (48 mg; 0.21 mmol) followed by 2,6-difluoropyridine (100 μL; 1.10 mmol). The reaction mixture was stirred at 80° C. overnight.

Sources & evidence

ORD record
ord-3e26ca6d6aa2466da188281bcffd0b29
Source dataset
uspto-grants-2014_05
Patent number
US08722746B2

Reaction notes

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