Hydrochloric Acid → HCID 66678582, compound

HRID 1025949Notes

Reaction equation

HRID 1025949 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[N:7][C:8]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[CH:10]=1)=[O:4].[OH-].[Li+].Cl>O1CCCC1.O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=[N:7][C:8]=2[O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:12][CH:13]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 666788605-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid methyl ester

Product 1

HCID 66678582HCID 66678582, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 0.865 g 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid methyl ester in 9.0 mL tetrahydrofuran was added 3.2 mL of a 1M of lithium hydroxide in water was added and the mixture was stirred at ambient temperature for 3 h. The reaction mixture was acidified with 1M hydrochloric acid. The solid was collected by filtration washed with water and dried under high vacuum to yield 0.805 g of the title compound as white solid, 331.1 (M−H)−.

Workup

  1. additionwas added
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-8a4e1236aa694865a47999e81188e732
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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