反应详情

温度

70 °C

9.58 g of potassium hydroxide (KOH) and 20.00 g of indole were added to 110.58 g of 1,3-dibromopropane and 450 mL of N,N-dimethylformamide (DMF), and the mixture was stirred at 70° C. for 8 hours. After cooling to room temperature, 1 L of distilled water was added to the reaction solution, and the resulting solution was extracted with 1 L of ethyl acetate. The organic layer was washed with 500 mL of distilled water five times, then concentrated and purified by column chromatography to obtain 27.24 g of N-(3-bromopropyl)-indole. Compounds (p-9) and (p-10) having a bromopropyl group shown below were also synthesized in the same manner.

1. temperatureAfter cooling to room temperature
2. extractionthe resulting solution was extracted with 1 L of ethyl acetate
3. washThe organic layer was washed with 500 mL of distilled water five times
4. concentrationconcentrated
5. custompurified by column chromatography