Hydrochloric Acid → HCID 66935799, compound

HRID 1028207Notes

Reaction equation

HRID 1028207 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=3[O:29][CH3:30])=[O:20])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:31]>C(OC(C)C)(C)C>[ClH:31].[F:28][C:26]1[CH:25]=[CH:24][C:23]([O:29][CH3:30])=[C:22]([NH:21][C:19]([NH:18][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:17][CH2:16]3)=[O:20])[CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66936453HCID 66936453, compound

Product 1

HCID 66935799HCID 66935799, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

A suspension of 6-[3-(5-fluoro-2-methoxy-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (1.20 g) obtained in Example (22a) and 4 N hydrochloric acid (1,4-dioxane solution, 10 mL) was stirred at room temperature for 15 hours and diluted with diisopropyl ether. The precipitate was collected by filtration and dried to obtain the title compound (1.20 g, 94%) as a light beige solid.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-3b63cf0cf0d248659004c66d89924b5a
Source dataset
uspto-grants-2014_05
Patent number
US08735425B2

Reaction notes

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