反应详情

温度

100 °C

Compound 83 (100 mg, 0.43 mmol), 4-(N,N-dimethylsulfonamidophenyl)boronic acid (198 mg, 0.87 mmol), Pd(OAc)2 (5 mg, 0.02 mmol), S-Phos (18 mg, 0.04 mmol), and K2CO3 (299 mg, 2.17 mmol) were dissolved in dioxane/H2O (2.2 mL, 10/1, v/v), and stirred overnight at 100° C. The reaction mixture was diluted with H2O/EtOAc. The resulting precipitate was filtered, washed with H2O/EtOAc, and dried under vacuum to provide 171 (120 mg, 73% yield) as a grey solid. LC-MS (M+H=380, obsd.=380).

1. filtrationThe resulting precipitate was filtered
2. washwashed with H2O/EtOAc
3. customdried under vacuum