Hydrochloric Acid → Flutazolam

HRID 102916Notes

Reaction equation

HRID 102916 reaction equation
[Br:26][CH2:27][CH2:28][OH:29].[CH3:31][N:32]([CH3:33])[CH:34]=[O:35].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:23]1)[C:7]1([c:16]3[c:17]([F:22])[cH:18][cH:19][cH:20][cH:21]3)[N:8]([CH2:9][C:10](=[O:12])[NH:11]2)[CH2:13][CH2:14][O:15]1.[ClH:30].[H-:24].[Na+:25].[OH2:36]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:23]1)[C:7]1([c:16]3[c:17]([F:22])[cH:18][cH:19][cH:20][cH:21]3)[N:8]([CH2:9][C:10](=[O:12])[N:11]2[CH2:27][CH2:28][OH:29])[CH2:13][CH2:14][O:15]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 108982-BromoethanolHCID 166653HydrideHCID 14909583HCID 14909583, compound

Product 1

HCID 3398Flutazolam

Sources & evidence

ORD record
ord-70a600634e454888b207ed88286d469b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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