反应详情

温度

0 °C

To a solution of benzhydryl 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate (syn isomer) (3 g) in dichloromethane (6 ml) and anisole (3 ml) was added dropwise trifluoroacetic acid (6 ml) at 0° C. The mixture was stirred at 0° C. for two hours. The mixture was poured into a chilled mixture of diisopropyl ether and n-hexane (1:1, V/V). The precipitates were collected by filtration and dried under reduced pressure to give 7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylic acid trifluoroacetate (syn isomer) (2.50 g).

1. filtrationThe precipitates were collected by filtration
2. customdried under reduced pressure