Dimethylformamide → HCID 14837827, compound

HRID 1030102Notes

Reaction equation

HRID 1030102 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10](Cl)[C:9]2[C:4](=[C:5]([Cl:14])[CH:6]=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[Na].[NH:16]1[CH:20]=[N:19][CH:18]=[N:17]1.CN(C)C=O>O>[N:16]1([C:10]2[C:9]3[C:4](=[C:5]([Cl:14])[CH:6]=[C:7]([Cl:13])[CH:8]=3)[N:3]=[C:2]([CH3:1])[CH:11]=2)[CH:20]=[N:19][CH:18]=[N:17]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 92571H-1,2,4-TriazoleHCID 2829664,6,8-trichloro-2-methylquinolineHCID 5360545Sodium

Product 1

HCID 14837827HCID 14837827, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2.46 g of 2-methyl-4,6,8-trichloro-quinoline, 1.82 g of the sodium salt of 1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 100° C. for 25 hours whereupon the reaction mixture is poured into 100 ml of water. The precipitated product is filtered. Thus 2.59 g of the desired compound are obtained, yield 93%. Mp.: 220°-222° C.

Workup

  1. filtrationThe precipitated product is filtered

Sources & evidence

ORD record
ord-21c07925908545599dead439afdcb8ae
Source dataset
uspto-grants-1992_04
Patent number
US05104884

Reaction notes

Loading…