Dimethylformamide → HCID 14837868, compound

HRID 1030106Notes

Reaction equation

HRID 1030106 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[CH:10][C:9]2[C:4](=[C:5]([CH3:14])[C:6]([Cl:13])=[CH:7][CH:8]=2)[N:3]=1.[Na].[NH:16]1[CH:20]=[N:19][CH:18]=[N:17]1.CN(C)C=O>O>[N:16]1([C:2]2[C:11]([CH3:12])=[CH:10][C:9]3[C:4](=[C:5]([CH3:14])[C:6]([Cl:13])=[CH:7][CH:8]=3)[N:3]=2)[CH:20]=[N:19][CH:18]=[N:17]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 92571H-1,2,4-TriazoleHCID 5360545SodiumHCID 170396772,7-Dichloro-3,8-dimethylquinoline

Product 1

HCID 14837868HCID 14837868, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2.26 g of 2,7-dichloro-3,8-dimethyl-quinoline, 1.1 g of the sodium salt of 1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 100° C. for 25 hours. The reaction mixture is poured into 100 ml of water and the precipitated product is filtered. Thus 2.48 g of the desired compound are obtained, yield 96%. Mp.: 147°-148° C.

Workup

  1. filtrationthe precipitated product is filtered

Sources & evidence

ORD record
ord-40713b55ed164b0392ab4198662a8448
Source dataset
uspto-grants-1992_04
Patent number
US05104884

Reaction notes

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