Dimethylformamide → HCID 14837869, compound

HRID 1030107Notes

Reaction equation

HRID 1030107 reaction equation
Cl[C:2]1[CH:11]=[C:10]([C:12]([Cl:15])([Cl:14])[Cl:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:16]([Cl:19])([Cl:18])[Cl:17])[CH:8]=2)[N:3]=1.[Na].[CH3:21][C:22]1[N:26]=[CH:25][NH:24][N:23]=1.CN(C)C=O>O>[CH3:21][C:22]1[N:26]=[CH:25][N:24]([C:2]2[CH:11]=[C:10]([C:12]([Cl:15])([Cl:14])[Cl:13])[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([C:16]([Cl:19])([Cl:18])[Cl:17])[CH:8]=3)[N:3]=2)[N:23]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 5360545SodiumHCID 19822132HCID 19822132, compoundHCID 178433329HCID 178433329, compound

Product 1

HCID 14837869HCID 14837869, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.99 g of 2-chloro-4,6-bis-trichloromethyl-quinoline, 1.26 g of the sodium salt of 3-methyl-1,2,4-triazole and 10 ml of dimethyl formamide is stirred at 100° C. for 20 hours. The reaction mixture is poured into 100 ml of water, the precipitated product is filtered and recrystallized from 10 ml of ethanol. Thus 2.76 g of the desired compound are obtained, yield 62%. M.p.: 169°-170° C.

Workup

  1. filtrationthe precipitated product is filtered
  2. customrecrystallized from 10 ml of ethanol

Sources & evidence

ORD record
ord-3837a4f61e554b6e8c5a376bb24a1589
Source dataset
uspto-grants-1992_04
Patent number
US05104884

Reaction notes

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