P-Cresol → HCID 12865384, compound

HRID 1030332Notes

Reaction equation

HRID 1030332 reaction equation
[K].[CH:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[CH:3]=1.C(S)CC.[Br:14][C:15](Br)([F:17])[F:16]>CN(C)C=O>[Br:14][C:15]([F:17])([F:16])[O:8][C:7]1[CH:6]=[CH:5][C:4]([CH3:9])=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 2879P-CresolHCID 6382DibromodifluoromethaneHCID 7848Propyl mercaptanHCID 5462222Potassium

Product 1

HCID 12865384HCID 12865384, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the process, 0.1 mole of potassium salt of p-cresol is dissolved in dimethylformamide, a catalytic amount of propanethiol is added, dibromodifluoromethane is further added, and reacted at 20° to 30° C. for 4 hours to obtain p-(bromodifluoromethoxy) toluene in a 21% yield.

Workup

  1. customreacted at 20° to 30° C. for 4 hours

Sources & evidence

ORD record
ord-463c2cfc6fc7475bbefaa2715d634b23
Source dataset
uspto-grants-1992_04
Patent number
US05105021

Reaction notes

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