Hydrochloric Acid → HCID 19822190, compound

HRID 1030408Notes

Reaction equation

HRID 1030408 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29](N)=[CH:28][CH:27]=1)([CH3:23])[CH2:9][C:8]2=[O:33])(=[O:3])[CH3:2].N([O-])=O.[Na+].[ClH:38].[C:39]([O:43][CH2:44][CH3:45])(=[O:42])[CH:40]=[CH2:41]>O.CC(C)=O>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[O:11][C:10]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:41][CH:40]([Cl:38])[C:39]([O:43][CH2:44][CH3:45])=[O:42])=[CH:28][CH:27]=1)([CH3:23])[CH2:9][C:8]2=[O:33])(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 19822257HCID 19822257, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 19822190HCID 19822190, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

Following the same procedure as described in Preparation 18, 9 g of 6-acetoxy-2-(4-aminophenoxymethyl)-2-methyl-7-(1,1,3,3-tetramethylbutyl) chroman-4-one (prepared as described in Preparation 24), 1.8 g of sodium nitrite, 10 ml of concentrated hydrochloric acid, 20 g of ethyl acrylate, 0.3 g of cuprous oxide, 100 ml of acetone and about 8 ml of water were reacted, to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f7b392fcb3614571ac7614ce64e78f74
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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