Hydrochloric Acid → HCID 19822173, compound

HRID 1030414Notes

Reaction equation

HRID 1030414 reaction equation
[C:1]([O:4][C:5]1[C:6]([CH3:27])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23](N)=[CH:22][N:21]=1)([CH3:17])[CH2:9][CH2:8]2)(=[O:3])[CH3:2].N([O-])=O.[Na+].[ClH:32].[C:33]([O:37][CH2:38][CH3:39])(=[O:36])[CH:34]=[CH2:35]>O.CC(C)=O>[C:1]([O:4][C:5]1[C:6]([CH3:27])=[C:7]2[C:12](=[C:13]([CH3:16])[C:14]=1[CH3:15])[O:11][C:10]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:35][CH:34]([Cl:32])[C:33]([O:37][CH2:38][CH3:39])=[O:36])=[CH:22][N:21]=1)([CH3:17])[CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 23668193Sodium NitriteHCID 54002701HCID 54002701, compound

Product 1

HCID 19822173HCID 19822173, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

Following the same procedure as described in Preparation 18, 4.5 g of 6-acetoxy-2-(5-aminopyridin-2-yloxymethyl)-2,5,7,8-tetramethylchroman (prepared as described in Preparation 37), 1.1 g of sodium nitrite, 5 ml of concentrated hydrochloric acid, 10 g of ethyl acrylate, 175 mg of cuprous oxide, 40 ml of acetone and about 2.5 g of water were reacted, to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2dbaba3cc00645a7997df07bcea824b5
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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