Water → HCID 14459480, compound

HRID 1031462Notes

Reaction equation

HRID 1031462 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[N+:12]([C:15]1[CH:16]=[C:17]([C:27]2[CH:28]([CH3:34])[CH2:29][C:30](=[O:33])[NH:31][N:32]=2)[CH:18]=[CH:19][C:20]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)([O-:14])=[O:13].C(N(CC)CC)C.O>ClCCCl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:24]2[CH2:25][CH2:26][N:21]([C:20]3[CH:19]=[CH:18][C:17]([C:27]4[CH:28]([CH3:34])[CH2:29][C:30](=[O:33])[NH:31][N:32]=4)=[CH:16][C:15]=3[N+:12]([O-:14])=[O:13])[CH2:22][CH2:23]2)=[O:8])=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 14459461HCID 14459461, compound

Product 1

HCID 14459480HCID 14459480, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

0.70 g (4.1 mmol) of 4-methoxybenzoyl chloride is added to a slurry of 1.0 g (3.15 mmol) of 6-[3-nitro-4-(1-piperazinyl)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone and 1.14 ml (8.2 mmol) of triethylamine in 40 ml of 1,2-dichloroethane and the reaction mixture is boiled under reflux for 0.5 h. It is then cooled to room temperature, 50 ml of water are added, and the organic phase is separated off.

Workup

  1. temperatureunder reflux for 0.5 h
  2. customthe organic phase is separated off

Sources & evidence

ORD record
ord-442b58d993bf4a53a1421f2d7f469f86
Source dataset
uspto-grants-1990_09
Patent number
US04954501

Reaction notes

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