Potassium Carbonate → HCID 14459491, compound

HRID 1031469Notes

Reaction equation

HRID 1031469 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[C:10]([N+:20]([O-:22])=[O:21])[CH:9]=2)=[N:6][NH:5][C:4](=[O:23])[CH2:3]1.Br[CH2:25][CH2:26][CH2:27][N:28]1[C:32](=[O:33])[C:31]2=[CH:34][CH:35]=[CH:36][CH:37]=[C:30]2[C:29]1=[O:38].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:19][CH2:18][N:17]([CH2:25][CH2:26][CH2:27][N:28]4[C:32](=[O:33])[C:31]5=[CH:34][CH:35]=[CH:36][CH:37]=[C:30]5[C:29]4=[O:38])[CH2:16][CH2:15]3)=[C:10]([N+:20]([O-:22])=[O:21])[CH:9]=2)=[N:6][NH:5][C:4](=[O:23])[CH2:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21611N-3-BromopropylphthalimideHCID 14459461HCID 14459461, compound

Product 1

HCID 14459491HCID 14459491, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.16 g (10 mmol) of 5-methyl-6-[3-nitro-4-(1-piperazinyl)-phenyl]-4,5-dihydro-3(2H)-pyridazinone, 2.68 g (10 mmol) of N-(3-bromopropyl)-phthalimide, 1.38 g (10 mmol) of potassium carbonate and 50 ml of dimethyl formamide is stirred at 100° C. for 24 hours.

Sources & evidence

ORD record
ord-fd0cd19d0cd0409484003116fe1d4d4a
Source dataset
uspto-grants-1990_09
Patent number
US04954501

Reaction notes

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