反应详情

In 80 ml of N,N-dimethylformamide is dissolved 10 g of 4-(2-aminophenyl)-2-phthalimidobutyric acid, and 6.7 g of diethyl phosphorocyanidate is added dropwise to the solution under ice-cooling with stirring. After the addition is complete, stirring is continued for 15 minutes, and 3.1 g of triethylamine is added dropwise to the mixture under ice cooling, followed by stirring under ice-cooling for 45 minutes and then at room temperature for 30 minutes. The reaction solution is diluted with 200 ml of water, followed by stirring for 1 hour, and the crystals, which separate out, are collected by filtration, dried and added to 100 ml of ethanol, followed by heating. After the solution is concentrated to about half of the original volume, the colorless prisms which separate out are collected by filtration to give 8.3 g of 3-phthalimido-1,3,4,5-tetrahydro-1-benzazepin-2-one. m.p. 261°-263° C.

1. additionis added dropwise to the solution under ice-
2. temperaturecooling
3. additionAfter the addition
4. stirringstirring
5. stirringby stirring under ice-
6. temperaturecooling for 45 minutes
7. waitat room temperature for 30 minutes
8. stirringby stirring for 1 hour
9. customthe crystals, which separate out
10. filtrationare collected by filtration
11. customdried
12. additionadded to 100 ml of ethanol
13. temperatureby heating
14. concentrationAfter the solution is concentrated to about half of the original volume
15. customthe colorless prisms which separate out
16. filtrationare collected by filtration