2,6-Dichlorobenzoyl chloride → Benzamide, 2,6-dichloro-N-[[4-(trifluoromethyl)phenyl]methyl]-

HRID 1032234Notes

Reaction equation

HRID 1032234 reaction equation
Cl.[F:2][C:3]([F:13])([F:12])[C:4]1[CH:11]=[CH:10][C:7]([CH2:8][NH2:9])=[CH:6][CH:5]=1.[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:16]=1[C:17](Cl)=[O:18]>O1CCCC1.C(N(CC)CC)C>[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:16]=1[C:17]([NH:9][CH2:8][C:7]1[CH:10]=[CH:11][C:4]([C:3]([F:12])([F:13])[F:2])=[CH:5][CH:6]=1)=[O:18]

Participants

5

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 160903514-(Trifluoromethyl)benzylamine Hydrochloride

Product 1

HCID 164153Benzamide, 2,6-dichloro-N-[[4-(trifluoromethyl)phenyl]methyl]-

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8471TriethylamineSolvent

Procedure

To 21.1 g (0.1 mole) of 4-trifluoromethylbenzylamine hydrochloride was added 20.9 g (0.10 mole) of 2,6-dichlorobenzoyl chloride in 200 ml of tetrahydrofuran. Then was added in 1 portion 30 ml triethylamine.

Sources & evidence

ORD record
ord-c7a60bc74be14d2b9d34342a61f22764
Source dataset
uspto-grants-1990_09
Patent number
US04957533

Reaction notes

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