Hydrochloric Acid → HCID 67819976, compound

HRID 1033058Notes

Reaction equation

HRID 1033058 reaction equation
[ClH:1].[NH2:2][C:3](=[N:19][S:20]([NH2:23])(=[O:22])=[O:21])[CH2:4][C:5]1[O:9][C:8]([C:10]2[N:11]=[C:12]([N:15]=[C:16]([NH2:18])[NH2:17])[S:13][CH:14]=2)=[CH:7][CH:6]=1.C(OC(C)C)(C)C>O1CCOCC1.CO>[ClH:1].[NH2:2][C:3](=[N:19][S:20]([NH2:23])(=[O:22])=[O:21])[CH2:4][C:5]1[O:9][C:8]([C:10]2[N:11]=[C:12]([N:15]=[C:16]([NH2:18])[NH2:17])[S:13][CH:14]=2)=[CH:7][CH:6]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 53801571HCID 53801571, compound

Product 1

HCID 67819976HCID 67819976, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4N-hydrogenchloride in 1,4-dioxane (2.2 ml) was added to a mixture of 4-[5-(2-amino-2-aminosulfonyliminoethyl)furan-2-yl]-2-(diaminomethyleneamino)thiazole (3.0 g) in methanol (60 ml) and the mixture was stirred at ambient temeprature for 4 hours. To a mixture was added a diisopropyl ether (30 ml) and the isolated precipitate was collected by filtration. The precipitate was recrystallized from an aqueous ethanol to give 4-[5-(2-amino-2-aminosulfonyliminoethyl)furan-2-yl]-2-(diaminomethyleneamino)thiazole hydrochloride (2.17 g).

Workup

  1. filtrationthe isolated precipitate was collected by filtration
  2. customThe precipitate was recrystallized from an aqueous ethanol

Sources & evidence

ORD record
ord-0003078b30a64bd0b016c18e2a2521e5
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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