Hydrochloric Acid → HCID 19086279, compound

HRID 1033063Notes

Reaction equation

HRID 1033063 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH2:19])=[O:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].[ClH:20].C(OC(C)C)(C)C>CO>[ClH:20].[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH2:19])=[O:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 10446374HCID 10446374, compound

Product 1

HCID 19086279HCID 19086279, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a mixture of 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole (15.4 g) in methanol (160 ml) was added a solution of 19% (W/V) hydrogen chloride in methanol (31.6 ml) and the mixture was stirred for an hour at ambient temperature. To a reaction mixture was added a isopropyl ether and the isolated precipitate was collected by filtration. The precipitate was recrystallized from an aqueous ethanol to give 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole hydrochloride (6.82 g).

Workup

  1. filtrationthe isolated precipitate was collected by filtration
  2. customThe precipitate was recrystallized from an aqueous ethanol

Sources & evidence

ORD record
ord-0e1be13571cd48639ca01e6f50ac3b67
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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