1,4-Dibromobutane → HCID 19024285, compound

HRID 1033709Notes

Reaction equation

HRID 1033709 reaction equation
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5](=[O:12])[NH:4][C:3](=[O:13])[CH2:2]1.[Br:14][CH2:15][CH2:16][CH2:17][CH2:18]Br.[H-].[Na+]>CN(C)C=O>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][N:4]1[C:5](=[O:12])[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:1][CH2:2][C:3]1=[O:13]

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 19024281HCID 19024281, compound

Product 1

HCID 19024285HCID 19024285, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 84.2 mg of 2,3,4,5-tetrahydro-1,4-benzodiazepine-3,5-dione dissolved in 10 ml of dimethylformamide was ice-cooled, and then 0.0874 ml (1.5 equivalents) of 1,4-dibromobutane and 23.0 mg (1.2 equivalents) of 60% sodium hydride were added, followed reaction treatment and purification were conducted in the desired compound (yield 64%)

Workup

  1. temperaturecooled
  2. customreaction treatment and purification

Sources & evidence

ORD record
ord-61254aacac244f42b561ce3b0b6b1582
Source dataset
uspto-grants-1994_05
Patent number
US05312625

Reaction notes

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