Trifluoroacetic acid → HCID 19024453, compound

HRID 1033810Notes

Reaction equation

HRID 1033810 reaction equation
[CH2:1]([N:5]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[S:31](=[O:38])(=[O:37])[NH:32]C(C)(C)C)=[CH:21][CH:20]=1)[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O.C1(OC)C=CC=CC=1>>[CH2:1]([N:5]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[S:31](=[O:37])(=[O:38])[NH2:32])=[CH:23][CH:24]=1)[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 19024473HCID 19024473, compound

Product 1

HCID 19024453HCID 19024453, compound

Procedure

The title compound was prepared from 1-[N-butyl-N-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]carbamoyl]-1,2,3,4-tetrahydroquinoline (from Step A) and TFA in the presence of anisole, according to the procedure of Example 4, Step B, to give a 97% yield of the desired material after flash chromatography as a foam, homogeneous by TLC in 95:5 CH2Cl2 --MeOH; FAB-MS m/e 478 (M+1)+.

Sources & evidence

ORD record
ord-a45dbc1e220d4a32a9df5e29cf043776
Source dataset
uspto-grants-1994_05
Patent number
US05312820

Reaction notes

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